بررسی اثرات موگادون Mogadon در درمان اسپاسم شیرخواران

          Among epileptic syndromes the infantile spasms ( west syndrome ) is the    most  malignant one and leads to  irreparable brain damage, which is    related directly to duration of spasms. The effectiveness of Mogadon    (Nitrazepam) on treatment of infantile spasms was studied for two-years    (1998-2000) at neurologic ward of Mofid children hospital , Tehran , Iran.           This was prospective uncontrolled clinical trial on 30 childs age 2-24    months with infantile spasms. Patients  received Mogadon (NZP) 0.5-1    mg/kg/hr in three divided dose with meal, the patients evaluated regard to    complete and relative control of seizure and drug side effects at the end of    2,4 and 6 weeks of therapy.           At the end of six weeks of therapy 63% were seizure free , 26% had    reduced frequency of siezure , and 47% had complete normalization of    tracing EEG.           Because of high-effectiveness , few side effects and low cost the    Mogadon (NZP) could be a drug of choice in treatment of infantile spasms.